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1.

Multi-omics analysis of mucosal and systemic immunity to SARS-CoV-2 after birth.

Wimmers, Florian; Burrell, Allison R; Feng, Yupeng; Zheng, Hong; Arunachalam, Prabhu S; Hu, Mengyun; Spranger, Sara; Nyhoff, Lindsay E; Joshi, Devyani; Trisal, Meera; Awasthi, Mayanka; Bellusci, Lorenza; Ashraf, Usama; Kowli, Sangeeta; Konvinse, Katherine C; Yang, Emily; Blanco, Michael; Pellegrini, Kathryn; Tharp, Gregory; Hagan, Thomas; Chinthrajah, R Sharon; Nguyen, Tran T; Grifoni, Alba; Sette, Alessandro; Nadeau, Kari C; Haslam, David B; Bosinger, Steven E; Wrammert, Jens; Maecker, Holden T; Utz, Paul J; Wang, Taia T; Khurana, Surender; Khatri, Purvesh; Staat, Mary A; Pulendran, Bali.

Cell; 186(21): 4632-4651.e23, 2023 10 12.

Artículo en Inglés | MEDLINE | ID: mdl-37776858

2.

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency.

Oda, Hirotsugu; Manthiram, Kalpana; Chavan, Pallavi Pimpale; Rieser, Eva; Veli, Önay; Kaya, Öykü; Rauch, Charles; Nakabo, Shuichiro; Kuehn, Hye Sun; Swart, Mariël; Wang, Yanli; Çelik, Nisa Ilgim; Molitor, Anne; Ziaee, Vahid; Movahedi, Nasim; Shahrooei, Mohammad; Parvaneh, Nima; Alipour-Olyei, Nasrin; Carapito, Raphael; Xu, Qin; Preite, Silvia; Beck, David B; Chae, Jae Jin; Nehrebecky, Michele; Ombrello, Amanda K; Hoffmann, Patrycja; Romeo, Tina; Deuitch, Natalie T; Matthíasardóttir, Brynja; Mullikin, James; Komarow, Hirsh; Stoddard, Jennifer; Niemela, Julie; Dobbs, Kerry; Sweeney, Colin L; Anderton, Holly; Lawlor, Kate E; Yoshitomi, Hiroyuki; Yang, Dan; Boehm, Manfred; Davis, Jeremy; Mudd, Pamela; Randazzo, Davide; Tsai, Wanxia Li; Gadina, Massimo; Kaplan, Mariana J; Toguchida, Junya; Mayer, Christian T; Rosenzweig, Sergio D; Notarangelo, Luigi D.

Nat Immunol; 25(5): 764-777, 2024 May.

Artículo en Inglés | MEDLINE | ID: mdl-38609546

3.

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions.

Hansen, Justin M; de Jong, Maarten F; Wu, Qi; Zhang, Li-Shu; Heisler, David B; Alto, Laura T; Alto, Neal M.

Cell; 184(12): 3178-3191.e18, 2021 06 10.

Artículo en Inglés | MEDLINE | ID: mdl-34022140

4.

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.

Abbott, Timothy R; Dhamdhere, Girija; Liu, Yanxia; Lin, Xueqiu; Goudy, Laine; Zeng, Leiping; Chemparathy, Augustine; Chmura, Stephen; Heaton, Nicholas S; Debs, Robert; Pande, Tara; Endy, Drew; La Russa, Marie F; Lewis, David B; Qi, Lei S.

Cell; 181(4): 865-876.e12, 2020 05 14.

Artículo en Inglés | MEDLINE | ID: mdl-32353252

5.

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells.

Vinogradova, Ekaterina V; Zhang, Xiaoyu; Remillard, David; Lazar, Daniel C; Suciu, Radu M; Wang, Yujia; Bianco, Giulia; Yamashita, Yu; Crowley, Vincent M; Schafroth, Michael A; Yokoyama, Minoru; Konrad, David B; Lum, Kenneth M; Simon, Gabriel M; Kemper, Esther K; Lazear, Michael R; Yin, Sifei; Blewett, Megan M; Dix, Melissa M; Nguyen, Nhan; Shokhirev, Maxim N; Chin, Emily N; Lairson, Luke L; Melillo, Bruno; Schreiber, Stuart L; Forli, Stefano; Teijaro, John R; Cravatt, Benjamin F.

Cell; 182(4): 1009-1026.e29, 2020 08 20.

Artículo en Inglés | MEDLINE | ID: mdl-32730809

6.

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody.

Singh, Mandeep; Jackson, Katherine J L; Wang, Jing J; Schofield, Peter; Field, Matt A; Koppstein, David; Peters, Timothy J; Burnett, Deborah L; Rizzetto, Simone; Nevoltris, Damien; Masle-Farquhar, Etienne; Faulks, Megan L; Russell, Amanda; Gokal, Divya; Hanioka, Asami; Horikawa, Keisuke; Colella, Alexander D; Chataway, Timothy K; Blackburn, James; Mercer, Tim R; Langley, David B; Goodall, D Margaret; Jefferis, Roy; Gangadharan Komala, Muralikrishna; Kelleher, Anthony D; Suan, Dan; Rischmueller, Maureen; Christ, Daniel; Brink, Robert; Luciani, Fabio; Gordon, Tom P; Goodnow, Christopher C; Reed, Joanne H.

Cell; 180(5): 878-894.e19, 2020 03 05.

Artículo en Inglés | MEDLINE | ID: mdl-32059783

7.

Social Minds Sync Alike.

Omer, David B; Zilkha, Noga; Kimchi, Tali.

Cell; 178(2): 272-274, 2019 07 11.

Artículo en Inglés | MEDLINE | ID: mdl-31299199

8.

Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants.

Johnston, Timothy S; Li, Shuk Hang; Painter, Mark M; Atkinson, Reilly K; Douek, Naomi R; Reeg, David B; Douek, Daniel C; Wherry, E John; Hensley, Scott E.

Immunity; 57(4): 912-925.e4, 2024 Apr 09.

Artículo en Inglés | MEDLINE | ID: mdl-38490198

9.

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.

Sullivan, William J; Mullen, Peter J; Schmid, Ernst W; Flores, Aimee; Momcilovic, Milica; Sharpley, Mark S; Jelinek, David; Whiteley, Andrew E; Maxwell, Matthew B; Wilde, Blake R; Banerjee, Utpal; Coller, Hilary A; Shackelford, David B; Braas, Daniel; Ayer, Donald E; de Aguiar Vallim, Thomas Q; Lowry, William E; Christofk, Heather R.

Cell; 175(1): 117-132.e21, 2018 09 20.

Artículo en Inglés | MEDLINE | ID: mdl-30197082

10.

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes.

Gee, Marvin H; Han, Arnold; Lofgren, Shane M; Beausang, John F; Mendoza, Juan L; Birnbaum, Michael E; Bethune, Michael T; Fischer, Suzanne; Yang, Xinbo; Gomez-Eerland, Raquel; Bingham, David B; Sibener, Leah V; Fernandes, Ricardo A; Velasco, Andrew; Baltimore, David; Schumacher, Ton N; Khatri, Purvesh; Quake, Stephen R; Davis, Mark M; Garcia, K Christopher.

Cell; 172(3): 549-563.e16, 2018 01 25.

Artículo en Inglés | MEDLINE | ID: mdl-29275860

11.

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.

Lee, Suk Hyung; Hu, Wenhuo; Matulay, Justin T; Silva, Mark V; Owczarek, Tomasz B; Kim, Kwanghee; Chua, Chee Wai; Barlow, LaMont J; Kandoth, Cyriac; Williams, Alanna B; Bergren, Sarah K; Pietzak, Eugene J; Anderson, Christopher B; Benson, Mitchell C; Coleman, Jonathan A; Taylor, Barry S; Abate-Shen, Cory; McKiernan, James M; Al-Ahmadie, Hikmat; Solit, David B; Shen, Michael M.

Cell; 173(2): 515-528.e17, 2018 04 05.

Artículo en Inglés | MEDLINE | ID: mdl-29625057

12.

Distinct Mesenchymal Lineages and Niches Promote Epithelial Self-Renewal and Myofibrogenesis in the Lung.

Zepp, Jarod A; Zacharias, William J; Frank, David B; Cavanaugh, Christina A; Zhou, Su; Morley, Michael P; Morrisey, Edward E.

Cell; 170(6): 1134-1148.e10, 2017 Sep 07.

Artículo en Inglés | MEDLINE | ID: mdl-28886382

13.

Adaptive plasticity of IL-10⁺ and IL-35⁺ T_reg cells cooperatively promotes tumor T cell exhaustion.

Sawant, Deepali V; Yano, Hiroshi; Chikina, Maria; Zhang, Qianxia; Liao, Mengting; Liu, Chang; Callahan, Derrick J; Sun, Zhe; Sun, Tao; Tabib, Tracy; Pennathur, Arjun; Corry, David B; Luketich, James D; Lafyatis, Robert; Chen, Wei; Poholek, Amanda C; Bruno, Tullia C; Workman, Creg J; Vignali, Dario A A.

Nat Immunol; 20(6): 724-735, 2019 06.

Artículo en Inglés | MEDLINE | ID: mdl-30936494

14.

Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.

Zammit, Nathan W; Siggs, Owen M; Gray, Paul E; Horikawa, Keisuke; Langley, David B; Walters, Stacey N; Daley, Stephen R; Loetsch, Claudia; Warren, Joanna; Yap, Jin Yan; Cultrone, Daniele; Russell, Amanda; Malle, Elisabeth K; Villanueva, Jeanette E; Cowley, Mark J; Gayevskiy, Velimir; Dinger, Marcel E; Brink, Robert; Zahra, David; Chaudhri, Geeta; Karupiah, Gunasegaran; Whittle, Belinda; Roots, Carla; Bertram, Edward; Yamada, Michiko; Jeelall, Yogesh; Enders, Anselm; Clifton, Benjamin E; Mabbitt, Peter D; Jackson, Colin J; Watson, Susan R; Jenne, Craig N; Lanier, Lewis L; Wiltshire, Tim; Spitzer, Matthew H; Nolan, Garry P; Schmitz, Frank; Aderem, Alan; Porebski, Benjamin T; Buckle, Ashley M; Abbott, Derek W; Ziegler, John B; Craig, Maria E; Benitez-Aguirre, Paul; Teo, Juliana; Tangye, Stuart G; King, Cecile; Wong, Melanie; Cox, Murray P; Phung, Wilson.

Nat Immunol; 20(10): 1299-1310, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31534238

15.

A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time.

Seo, Daeha; Southard, Kaden M; Kim, Ji-Wook; Lee, Hyun Jung; Farlow, Justin; Lee, Jung-Uk; Litt, David B; Haas, Thomas; Alivisatos, A Paul; Cheon, Jinwoo; Gartner, Zev J; Jun, Young-Wook.

Cell; 165(6): 1507-1518, 2016 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-27180907

16.

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Sykes, David B; Kfoury, Youmna S; Mercier, François E; Wawer, Mathias J; Law, Jason M; Haynes, Mark K; Lewis, Timothy A; Schajnovitz, Amir; Jain, Esha; Lee, Dongjun; Meyer, Hanna; Pierce, Kerry A; Tolliday, Nicola J; Waller, Anna; Ferrara, Steven J; Eheim, Ashley L; Stoeckigt, Detlef; Maxcy, Katrina L; Cobert, Julien M; Bachand, Jacqueline; Szekely, Brian A; Mukherjee, Siddhartha; Sklar, Larry A; Kotz, Joanne D; Clish, Clary B; Sadreyev, Ruslan I; Clemons, Paul A; Janzer, Andreas; Schreiber, Stuart L; Scadden, David T.

Cell; 167(1): 171-186.e15, 2016 Sep 22.

Artículo en Inglés | MEDLINE | ID: mdl-27641501

17.

The solute carrier SPNS2 recruits PI(4,5)P₂ to synergistically regulate transport of sphingosine-1-phosphate.

Tang, Haiping; Li, Huanyu; Prakaash, Dheeraj; Pedebos, Conrado; Qiu, Xingyu; Sauer, David B; Khalid, Syma; Duerr, Katharina; Robinson, Carol V.

Mol Cell; 83(15): 2739-2752.e5, 2023 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-37499662

18.

Contribution of adaptive immunity to human COPD and experimental models of emphysema.

Kheradmand, Farrah; Zhang, Yun; Corry, David B.

Physiol Rev; 103(2): 1059-1093, 2023 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-36201635

19.

Multisystem physiological perspective of human frailty and its modulation by physical activity.

Taylor, Joseph A; Greenhaff, Paul L; Bartlett, David B; Jackson, Thomas A; Duggal, Niharika A; Lord, Janet M.

Physiol Rev; 103(2): 1137-1191, 2023 04 01.

Artículo en Inglés | MEDLINE | ID: mdl-36239451

20.

Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization.

Wu, Yifan; Zeng, Zhimin; Guo, Yubiao; Song, Lizhen; Weatherhead, Jill E; Huang, Xinyan; Zeng, Yuying; Bimler, Lynn; Chang, Cheng-Yen; Knight, John M; Valladolid, Christian; Sun, Hua; Cruz, Miguel A; Hube, Bernhard; Naglik, Julian R; Luong, Amber U; Kheradmand, Farrah; Corry, David B.

Immunity; 54(11): 2595-2610.e7, 2021 11 09.

Artículo en Inglés | MEDLINE | ID: mdl-34506733

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